Projects
Targeting Syk in M2 Macrophages and Investigation of Syk Enzyme Inhibition Affects on the Secretome of Macrophages and Its Consequences on Mesothelioma, TÜBİTAK 1001, Coordinator: Emel Başak GENCER AKÇOK.
Integrative Transcriptomic, Proteomic, and Machine Learning Approach to Identifying the Role of lncRNA XIST in MS Etiopathogenesis Using Human Vascular Brain Organoids.TÜBİTAK 1001 KBAG (124Z081), Coordinator: Alaattin ŞEN.
Recombinant Production of New Long-Acting GLP-1 Receptor Agonists in Pichia pastoris and Determination of Their In Vitro Bioactivities, TÜSEB Group B, 2024, Researcher: Aysun ADAN.
Investigation of the Role of FLCN-1 Protein Serving as GAP with RPI-2, which is GAP, and ARL-3 and RAGA-1, which are other Small GTPases in Ciliabiogenesis, TÜBİTAK 1001, 2023-2025. Coordinator: Sebiha ÇEVİK KAPLAN.
Integrated Analysis of Genome-Wide DNA Methylome and Transcriptomic Alterations in FLT3-ITD Positive Acute Myeloid Leukemia with Acquired Midostaurin Resistance: Identification of Novel Molecular Targets Regulated via DNA Methylation in Overcoming Resistance, TÜBİTAK 1001, 2024-2027, Coordinator: Aysun ADAN.
The Effect of Crystallographic Orientation on Bone Tissue Development Process in Metallic Biomaterials Produced via Additive Manufacturing, TÜBİTAK 1001, 2023-2025, Researcher: Aysun ADAN.
Investigation of the Effects of Titanium Dioxide Nanoparticles on Ehrlich Ascites Tumor Cells, Erciyes University BAP, 2022-2024, Researcher: Aysun ADAN.
Investigation of ARL13B-Dependent Association of Two Different Cilia Types in Caenorhabditis elegans, 2022-ACİL-10, Coordinator: Sebiha ÇEVİK KAPLAN.
Targeting of SH2 Domains in Syk Kinase Proteins and Investigation of This Targeting in Vitro, TÜSEB Group A, Coordinator: Emel Başak GENCER AKÇOK.
Investigation of the Role of Bardet-Biedl Syndrome Proteins in Cilia Entry, TÜBİTAK 1002 (621638), Coordinator: Sebiha ÇEVİK KAPLAN.
Synthesis, Function and Therapeutic Potential of Immunoglobulin G Glycan Structures, TÜBİTAK 1001 (121S437), Coordinator: Altan ERCAN.
Identification of Trueperella pyogenes Pyolosin-specific Nanobodies Using Proteogenomic Approaches, TÜBİTAK 1001 (121O664), Coordinator: Şerife AYAZ GÜNER.
The Roles of Sphingosine Kinase and Glucosyl Ceramide Synthase in Midostaurin Resistant FLT3-ITD Positive Acute Myeloid Leukemia. Novartis, Material Support, 2021- 2024. Coordinator: Aysun ADAN.
Microencapsulation of Sugar Beet Leaf Protein Hydrolysates which Has Improved Bioactivity by Double Layer Emulsion. TÜBİTAK-3501, 2021- 2024. Researcher: Aysun ADAN.
The Role of Genetically Targeting Sphingosine Kinase and Glucosyl Ceramide Synthase in Reversing Midostaurin Resistance in Experimental FLT3-ITD Positive Acute Myeloid Leukemia. TÜBİTAK, Coordinator: Aysun ADAN.
Investigation at Molecular Level of the Role of Sphingosine Kinase and Glucosyl Ceramide Synthase in the Development of Resistance in Midostaurin Resistant FLT3-ITD Positive Acute Myeloid Leukemia. Turkish Hematology Association, Coordinator: Aysun ADAN.
Multiple Targeting on Neuroinflammation for Multiple Sclerosis and Cognitive Disorders: Design, Synthesis and Determination of Bioactivity in Brain Organoids of Ciproxifan and Fingolimod Based Hybrid Derivatives, TÜBİTAK 1001 (119Z389), Coordinator: Alaattin ŞEN.
Molecular Determination of the Effects of Histone Deacetylase Inhibitors on Pten / PI3k / Akt / Mtor Pathway and Cholangiocarcinoma Development, TÜBİTAK 3501 (217S660), Coordinator: Emel Başak GENCER AKÇOK.
Determination of New Chimeric Antigen Receptor (CAR) Targets by Investigating B Cell Acute Lymphoblastic Leukemia (B-ALL) Surface Proteome, TÜBİTAK 1001 (119S457), Coordinator: Servet Özcan, Researcher: Şerife AYAZ GÜNER.
Functional Characterization of C. Elegans Mutant Joubert Syndrome Gene CEP41 Obtained by CRISPR, TÜBİTAK 1001 (118S552), Coordinator: Oktay KAPLAN, Researcher: Sebiha ÇEVİK KAPLAN.
Determination and Characterization of New Cilia Genes, TÜBİTAK 3001 (118Z471), Coordinator: Oktay KAPLAN, Researcher: Sebiha ÇEVİK KAPLAN.
Completed Projects
Evaluation of In Vivo Efficiency of Olean-12-En-28-Ol, 3ß Pentacosanoate (Opc) Isolated from Capparis Ovata for Symptomatic Treatment of Multiple Sclerosis, TÜBİTAK 1001 (117S293), 2021. Coordinator: Alaattin ŞEN.
The Therapeutic Potential of Resveratrol in Ph + Acute Lymphoblastic Leukemia and the Role of Ceramide Metabolism in Induced Apoptosis by Resveratrol, TÜBİTAK, 315S248, 2016-2018. Coordinator: Aysun ADAN.
Regulation of Hedgehog and Autophagy Pathways for Acute Myeloid Leukemia Treatment, TÜBİTAK, 216S319, 2017-2019. Coordinator: Mona EL KHATIB.
Development of Breast Cancer Targeted, Increased Stability, pH Sensitive for Two Sites, Drug Conjugated and Multifunctional Micellar Nanocarriers and Determination of In Vitro Efficacy, TÜBİTAK 1001-116R057, 2017-2019. Researcher: Yusuf BARAN.
Development of Multifunctional, Targeted, Specific Nanocarriers for the Treatment of Breast Cancer, Investigation of In Vitro and In Vivo Activities, - TÜBİTAK 216S639, Researcher: Yusuf BARAN.
Investigation of the Role of the SMC1 Gene Which Has Possible Role in Cilia and Silya Diseases in Cilia Biogenesis, BAP, FYL-2017-100, 2017-2018. Coordinator: Sebiha ÇEVİK KAPLAN.
The Therapeutic Potential of Resveratrol in FLT3 + Acute Myeloid Leukemia and the Role of Ceramide Metabolism in Triggered Apoptosis by Resveratrol, AGU-BAP, 66, 2016-2017. Coordinator: Aysun ADAN.
A New Treatment Approach in Ph + Acute Lymphoblastic Leukemia; Targeting the Sphingosine Kinase Signaling Pathway, Eczacıbaşı Holding, 2015-2016. Coordinator: Yusuf Baran, Researcher: Aysun ADAN.
A New Treatment Approach in Ph + Acute Lymphoblastic Leukemia; Targeting the Sphingosine Kinase Signaling Pathway, AGU-BAP, 2015-2017. Researcher: Aysun ADAN.
Expression Levels of JAK-STAT Signaling Pathway Genes in Chronic Myeloid Leukemia Patients and Their Effects on The Clinical Course. Güven Hospital, 2015-2016. Coordinator: Yusuf BARAN.
Fine Tuning of Hedgehog and Autophagy Pathways to Fight with Cholangiocarcinoma, AGU-BAP, TAB-2016-67, 2016-2018. Coordinator: Mona EL KHATIB.
Investigation of the Relationship Between C.Elegans Kinesin 8KLP13 Protein and Ciliopathy Disease Genes, Investigation of The Molecular Mechanism of Ciliopathy Diseases, BAP, TAB-2016-68, 2016-2016. Coordinator: Sebiha ÇEVİK KAPLAN.